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gsr  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology gsr
    <t>NRF2</t> activation in response to oxidative stress in the trabecular meshwork (TM). (A) Volcano plot of differentially expressed genes (DEGs) in human TM cells with or without tert-butyl hydroperoxide (tBHP) treatment. (B) Gene set enrichment analysis (GSEA) of human TM cells with or without tBHP treatment. (C) mRNA expression of NRF2, GPX4, <t>GSR,</t> SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. * P < 0.05, *** P < 0.001. (D) Protein expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. (E) Immunofluorescence staining of NRF2 (red) and the TM marker α-SMA (green) in human corneoscleral rings, rhesus monkey eyes, and mouse eyes. Nuclei are counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue).
    Gsr, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 145 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gsr/pmc13003157-228-14-16?v=Santa+Cruz+Biotechnology
    Average 95 stars, based on 145 article reviews
    gsr - by Bioz Stars, 2026-07
    95/100 stars

    Images

    1) Product Images from "NRF2 Deficiency Disrupts Mitochondrial Homeostasis via NDUFS7 in Trabecular Meshwork"

    Article Title: NRF2 Deficiency Disrupts Mitochondrial Homeostasis via NDUFS7 in Trabecular Meshwork

    Journal: Research

    doi: 10.34133/research.1203

    NRF2 activation in response to oxidative stress in the trabecular meshwork (TM). (A) Volcano plot of differentially expressed genes (DEGs) in human TM cells with or without tert-butyl hydroperoxide (tBHP) treatment. (B) Gene set enrichment analysis (GSEA) of human TM cells with or without tBHP treatment. (C) mRNA expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. * P < 0.05, *** P < 0.001. (D) Protein expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. (E) Immunofluorescence staining of NRF2 (red) and the TM marker α-SMA (green) in human corneoscleral rings, rhesus monkey eyes, and mouse eyes. Nuclei are counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue).
    Figure Legend Snippet: NRF2 activation in response to oxidative stress in the trabecular meshwork (TM). (A) Volcano plot of differentially expressed genes (DEGs) in human TM cells with or without tert-butyl hydroperoxide (tBHP) treatment. (B) Gene set enrichment analysis (GSEA) of human TM cells with or without tBHP treatment. (C) mRNA expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. * P < 0.05, *** P < 0.001. (D) Protein expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. (E) Immunofluorescence staining of NRF2 (red) and the TM marker α-SMA (green) in human corneoscleral rings, rhesus monkey eyes, and mouse eyes. Nuclei are counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue).

    Techniques Used: Activation Assay, Expressing, Immunofluorescence, Staining, Marker



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    gsr  (Santa Cruz Biotechnology)
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    <t>NRF2</t> activation in response to oxidative stress in the trabecular meshwork (TM). (A) Volcano plot of differentially expressed genes (DEGs) in human TM cells with or without tert-butyl hydroperoxide (tBHP) treatment. (B) Gene set enrichment analysis (GSEA) of human TM cells with or without tBHP treatment. (C) mRNA expression of NRF2, GPX4, <t>GSR,</t> SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. * P < 0.05, *** P < 0.001. (D) Protein expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. (E) Immunofluorescence staining of NRF2 (red) and the TM marker α-SMA (green) in human corneoscleral rings, rhesus monkey eyes, and mouse eyes. Nuclei are counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue).
    Gsr, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gsr/pmc13003157-228-14-16?v=Santa+Cruz+Biotechnology
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    Image Search Results


    NRF2 activation in response to oxidative stress in the trabecular meshwork (TM). (A) Volcano plot of differentially expressed genes (DEGs) in human TM cells with or without tert-butyl hydroperoxide (tBHP) treatment. (B) Gene set enrichment analysis (GSEA) of human TM cells with or without tBHP treatment. (C) mRNA expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. * P < 0.05, *** P < 0.001. (D) Protein expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. (E) Immunofluorescence staining of NRF2 (red) and the TM marker α-SMA (green) in human corneoscleral rings, rhesus monkey eyes, and mouse eyes. Nuclei are counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue).

    Journal: Research

    Article Title: NRF2 Deficiency Disrupts Mitochondrial Homeostasis via NDUFS7 in Trabecular Meshwork

    doi: 10.34133/research.1203

    Figure Lengend Snippet: NRF2 activation in response to oxidative stress in the trabecular meshwork (TM). (A) Volcano plot of differentially expressed genes (DEGs) in human TM cells with or without tert-butyl hydroperoxide (tBHP) treatment. (B) Gene set enrichment analysis (GSEA) of human TM cells with or without tBHP treatment. (C) mRNA expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. * P < 0.05, *** P < 0.001. (D) Protein expression of NRF2, GPX4, GSR, SLC7A11, HMOX1, GCLM, NQO1, and GCLC in human TM cells with or without tBHP exposure. (E) Immunofluorescence staining of NRF2 (red) and the TM marker α-SMA (green) in human corneoscleral rings, rhesus monkey eyes, and mouse eyes. Nuclei are counterstained with 4′,6-diamidino-2-phenylindole (DAPI) (blue).

    Article Snippet: Antibodies used were listed as follows: NRF2 (12721, CST), NDUFS7 (PA5-106367, Thermo Fisher Scientific), GSR (SC-133245, Santa Cruz Biotechnology), SLC7A11 (ab307601, Abcam), HMOX1 (10701-1-AP, Proteintech), GCLM (14241-1-AP, Proteintech), NQO1 (11451-1-AP, Proteintech), GCLC (12601-1-AP, Proteintech), GPX4 (67763-1-Ig, Proteintech), GAPDH (SC-137179, Santa Cruz Biotechnology), and β-actin (SC-47778, Santa Cruz Biotechnology).

    Techniques: Activation Assay, Expressing, Immunofluorescence, Staining, Marker